CovidSeniorV1, Main, Exploration, bibRecord, 000842

COVID-19: The Influence of ACE Genotype and ACE-I and ARBs on the Course of SARS-CoV-2 Infection in Elderly Patients.

Identifieur interne : 000842 ( Main/Exploration ); précédent : 000841; suivant : 000843

COVID-19: The Influence of ACE Genotype and ACE-I and ARBs on the Course of SARS-CoV-2 Infection in Elderly Patients.

Auteurs : Jerzy Sie Ko [Pologne] ; Maciej Kotowski [Pologne] ; Anna Bogacz [Pologne] ; Kacper Lechowicz [Pologne] ; Sylwester Dro D Al [Pologne] ; Jakub Rosik [Pologne] ; Marek Sietnicki [Pologne] ; Magdalena Sie Ko [Pologne] ; Katarzyna Kotfis [Pologne]

Source :

Clinical interventions in aging [ 1178-1998 ] ; 2020.

RBID : pubmed:32764907

Descripteurs français

KwdFr :
- Animaux (MeSH), Betacoronavirus (MeSH), Comorbidité (MeSH), Fréquence d'allèle (MeSH), Génotype (MeSH), Humains (MeSH), Infections à coronavirus (génétique), Infections à coronavirus (thérapie), Maladies héréditaires de l'oeil (MeSH), Pandémies (MeSH), Pneumopathie virale (génétique), Pneumopathie virale (thérapie), Rétinopathies (MeSH), Sujet âgé (MeSH).
MESH :
- génétique : Infections à coronavirus, Pneumopathie virale.
- thérapie : Infections à coronavirus, Pneumopathie virale.
- Animaux, Betacoronavirus, Comorbidité, Fréquence d'allèle, Génotype, Humains, Maladies héréditaires de l'oeil, Pandémies, Rétinopathies, Sujet âgé.

English descriptors

KwdEn :
- Aged (MeSH), Animals (MeSH), Betacoronavirus (MeSH), Comorbidity (MeSH), Coronavirus Infections (genetics), Coronavirus Infections (therapy), Eye Diseases, Hereditary (MeSH), Gene Frequency (MeSH), Genotype (MeSH), Humans (MeSH), Pandemics (MeSH), Pneumonia, Viral (genetics), Pneumonia, Viral (therapy), Retinal Diseases (MeSH).
MESH :
- genetics : Coronavirus Infections, Pneumonia, Viral.
- therapy : Coronavirus Infections, Pneumonia, Viral.
- Aged, Animals, Betacoronavirus, Comorbidity, Eye Diseases, Hereditary, Gene Frequency, Genotype, Humans, Pandemics, Retinal Diseases.

Abstract

Since the beginning of 2020, the whole world has been struggling with the pandemic of Coronavirus Disease 2019 (COVID-19) caused by a novel coronavirus SARS-CoV-2. The SARS-CoV-2 infection depends on ACE2, TMPRSS2, and CD147, which are expressed on host cells. Several studies suggest that some single nucleotide polymorphisms (SNPs) of ACE2 might be a risk factor of COVID-19 infection. Genotypes affect ACE2 structure, its serum concentration, and levels of circulating angiotensin (1-7). Moreover, there is evidence that ACE genotype affects the outcomes of acute respiratory distress syndrome (ARDS) treatment, the most severe consequence of SARS-CoV-2 infection. COVID-19 morbidity, infection course, and mortality might depend on ACE D allele frequency. The aim of this narrative review was to analyze and identify the mechanisms of ACE-I and ARBs with particular emphasis on angiotensin receptors and their polymorphism in the light of COVID-19 pandemic as these medications are commonly prescribed to elderly patients. There is no direct evidence yet for ACE-I or ARBs in the treatment of COVID-19. However, for those already taking these medications, both the European Society of Cardiology and the American College of Cardiology recommend continuing the treatment, because at present, there is no clear clinical or scientific evidence to justify the discontinuation of ACE-I or ARBs. Individualized treatment decisions should be based on the clinical condition and co-morbidities of each patient.

DOI: 10.2147/CIA.S261516
PubMed: 32764907
PubMed Central: PMC7382582

Affiliations:

Pologne

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000763
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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term>
<term>Animals (MeSH)</term>
<term>Betacoronavirus (MeSH)</term>
<term>Comorbidity (MeSH)</term>
<term>Coronavirus Infections (genetics)</term>
<term>Coronavirus Infections (therapy)</term>
<term>Eye Diseases, Hereditary (MeSH)</term>
<term>Gene Frequency (MeSH)</term>
<term>Genotype (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (genetics)</term>
<term>Pneumonia, Viral (therapy)</term>
<term>Retinal Diseases (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Betacoronavirus (MeSH)</term>
<term>Comorbidité (MeSH)</term>
<term>Fréquence d'allèle (MeSH)</term>
<term>Génotype (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Infections à coronavirus (génétique)</term>
<term>Infections à coronavirus (thérapie)</term>
<term>Maladies héréditaires de l'oeil (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (génétique)</term>
<term>Pneumopathie virale (thérapie)</term>
<term>Rétinopathies (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
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<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Animals</term>
<term>Betacoronavirus</term>
<term>Comorbidity</term>
<term>Eye Diseases, Hereditary</term>
<term>Gene Frequency</term>
<term>Genotype</term>
<term>Humans</term>
<term>Pandemics</term>
<term>Retinal Diseases</term>
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<term>Comorbidité</term>
<term>Fréquence d'allèle</term>
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<term>Humains</term>
<term>Maladies héréditaires de l'oeil</term>
<term>Pandémies</term>
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<front><div type="abstract" xml:lang="en">Since the beginning of 2020, the whole world has been struggling with the pandemic of Coronavirus Disease 2019 (COVID-19) caused by a novel coronavirus SARS-CoV-2. The SARS-CoV-2 infection depends on ACE2, TMPRSS2, and CD147, which are expressed on host cells. Several studies suggest that some single nucleotide polymorphisms (SNPs) of ACE2 might be a risk factor of COVID-19 infection. Genotypes affect ACE2 structure, its serum concentration, and levels of circulating angiotensin (1-7). Moreover, there is evidence that ACE genotype affects the outcomes of acute respiratory distress syndrome (ARDS) treatment, the most severe consequence of SARS-CoV-2 infection. COVID-19 morbidity, infection course, and mortality might depend on ACE D allele frequency. The aim of this narrative review was to analyze and identify the mechanisms of ACE-I and ARBs with particular emphasis on angiotensin receptors and their polymorphism in the light of COVID-19 pandemic as these medications are commonly prescribed to elderly patients. There is no direct evidence yet for ACE-I or ARBs in the treatment of COVID-19. However, for those already taking these medications, both the European Society of Cardiology and the American College of Cardiology recommend continuing the treatment, because at present, there is no clear clinical or scientific evidence to justify the discontinuation of ACE-I or ARBs. Individualized treatment decisions should be based on the clinical condition and co-morbidities of each patient.</div>
</front>
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<Day>13</Day>
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<JournalIssue CitedMedium="Internet"><Volume>15</Volume>
<PubDate><Year>2020</Year>
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<Title>Clinical interventions in aging</Title>
<ISOAbbreviation>Clin Interv Aging</ISOAbbreviation>
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<ArticleTitle>COVID-19: The Influence of ACE Genotype and ACE-I and ARBs on the Course of SARS-CoV-2 Infection in Elderly Patients.</ArticleTitle>
<Pagination><MedlinePgn>1231-1240</MedlinePgn>
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<Abstract><AbstractText>Since the beginning of 2020, the whole world has been struggling with the pandemic of Coronavirus Disease 2019 (COVID-19) caused by a novel coronavirus SARS-CoV-2. The SARS-CoV-2 infection depends on ACE2, TMPRSS2, and CD147, which are expressed on host cells. Several studies suggest that some single nucleotide polymorphisms (SNPs) of ACE2 might be a risk factor of COVID-19 infection. Genotypes affect ACE2 structure, its serum concentration, and levels of circulating angiotensin (1-7). Moreover, there is evidence that ACE genotype affects the outcomes of acute respiratory distress syndrome (ARDS) treatment, the most severe consequence of SARS-CoV-2 infection. COVID-19 morbidity, infection course, and mortality might depend on ACE D allele frequency. The aim of this narrative review was to analyze and identify the mechanisms of ACE-I and ARBs with particular emphasis on angiotensin receptors and their polymorphism in the light of COVID-19 pandemic as these medications are commonly prescribed to elderly patients. There is no direct evidence yet for ACE-I or ARBs in the treatment of COVID-19. However, for those already taking these medications, both the European Society of Cardiology and the American College of Cardiology recommend continuing the treatment, because at present, there is no clear clinical or scientific evidence to justify the discontinuation of ACE-I or ARBs. Individualized treatment decisions should be based on the clinical condition and co-morbidities of each patient.</AbstractText>
<CopyrightInformation>© 2020 Sieńko et al.</CopyrightInformation>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sieńko</LastName>
<ForeName>Jerzy</ForeName>
<Initials>J</Initials>
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</AffiliationInfo>
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<ForeName>Anna</ForeName>
<Initials>A</Initials>
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<AffiliationInfo><Affiliation>Department of Pharmacology and Phytochemistry, Institute of Natural Fibers and Medicinal Plants, Poznan, Poland.</Affiliation>
</AffiliationInfo>
</Author>
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</AffiliationInfo>
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<AffiliationInfo><Affiliation>Department of Pharmacokinetics and Monitored Therapy, Pomeranian Medical University in Szczecin, Szczecin, Poland.</Affiliation>
</AffiliationInfo>
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<ForeName>Jakub</ForeName>
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<AffiliationInfo><Affiliation>Department of Physiology, Pomeranian Medical University in Szczecin, Szczecin, Poland.</Affiliation>
</AffiliationInfo>
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</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sieńko</LastName>
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<Initials>M</Initials>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Kotfis</LastName>
<ForeName>Katarzyna</ForeName>
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COVID-19: The Influence of ACE Genotype and ACE-I and ARBs on the Course of SARS-CoV-2 Infection in Elderly Patients.

COVID-19: The Influence of ACE Genotype and ACE-I and ARBs on the Course of SARS-CoV-2 Infection in Elderly Patients.

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